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Amitriptyline (trade names include Elavil; Endep; Amineurin; Amytril; Amitriptyline Actavis; Sarotena; Sandoz Amitriptyline; Elatrolet; Apo-Amitriptyline; Eliwel; Laroxyl; Saroten; Tryptanol; Tryptizol) is a tricyclic antidepressant (TCA) and anti-anxiety medication from non-selective monoamine reuptake inhibitors pharmacological group. This medicine is used to treat depression, anxiety and other diseases. It works by affecting chemicals in human brain that may become unbalanced and cause depression. Generic Elavil or Endep is a safe, reliable medication, and one of the best anti-depression treatments available.
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General information about Amitriptyline (Elavil, Endep):
Medical and pharmaceutical categories for amitriptyline:
Tricyclics and other norepinephrine-reuptake inhibitors
The Anatomical Therapeutic Chemical (ATC) classification system amitriptyline codes:
N - Nervous system
N06 - Psychoanaleptics
N06A - Antidepressants
N06AA - Non-selective monoamine reuptake inhibitors
N06AA09 - Amitriptyline
N06C - Psycholeptics and psychoanaleptics in combination
N06CA - Antidepressants in combination with psycholeptics
N06CA01 - Amitriptyline and psycholeptics
Amitriptyline in The International Statistical Classification of Diseases and Related Health Problems (ICD-10, World Health Organization) codes:
Bipolar affective disorder - F31
Depressive episode - F32
Recurrent depressive disorder - F33
Persistent mood [affective] disorders - F34
Phobic anxiety disorders - F40
Pain, not elsewhere classified - R52
Pregnancy and breastfeeding categories for Amitriptyline (Endep, Elavil):
C - Australia
C - United States (Risk cannot be ruled out)
Salts and other amitriptyline forms used as active pharmaceutical ingredients (API):
Synonyms of amitriptyline, international and chemical names:
Best known amitriptyline brands, generics and trade names in various countries:
Amineurin - Hexal
Amioxid - Neuraxpharm Arzneimittel
Amitril - Warner Chilcott
Amitrip - East West Pharma; Sanofi-Aventis; Pacific Pharmaceuticals
Amit - Orchid Chemicals & Pharmaceuticals
Amitriptylin - Betapharm Arzneimittel; Desitin Arzneimittel; Neuraxpharm Arzneimittel; Teva; Zentiva
Amitriptyline - Actavis; Apotex; Caraco; Clonmel Healthcare; Mutual Pharmaceuticals; Mylan; Nycomed; Pliva; Pro Doc; Roxane Laboratories; Sandoz; Teva; UCB Pharma; Watson Pharmaceuticals; West-Ward Pharmaceuticals
Amytril - Cristalia Produtos Quimicos Farmaceuticos
Amyzol - Lek
Anapsique - Psicofarma Laboratorio
Apo-Amitriptyline - Apotex; Hind Wing; Nhan Tam; Pharmaforte
Deprelio - Estedi
Elatrolet - Teva
Elavil - Merck; AA Pharma; AstraZeneca; DDSA Pharmaceuticals; Gerda Laboratoires; Ontario; Substipharm Laboratoire
Eliwel - Sun Pharmaceutical Industries
Endep - Alphapharm; Merck; Roche; Sandoz; Summit; Zuellig Pharma
Laroxyl - Roche
Novoprotect Retard - Merck
PMS-Amitriptyline - Pharmascience
Redomex - Lundbeck
Saroten - Bayer Schering Pharma; Gerolymatos; Lundbeck; Roche
Sarotena - Lundbeck
Sarotex - Lundbeck
Stelminal - Coup
Syneudon - Krewel Meuselbach
Teperin - Extractum Pharma
Trepiline - Aspen Pharmacare
Trilin - Triton Health Care
Triptizol - Specialita Igienico Terapeutiche
Triptyl - Orion Pharma
Triptyline - Medifive Pharma
Tryptanol - Merck; M & H Manufacturing
Tryptil - Cristalia Produtos Quimicos Farmaceuticos
Tryptizol - Merck; Fulcrum Medical Marketing
Tryptomer - Wockhardt
Pharmaceutical active ingredients used in medicine in combinations with amitriptyline:
Vitamin B6 (Pyridoxine)
Some other medications in Elavil and Endep (Amitriptyline) pharmacological classes:
Aventyl; Pamelor (Nortriptyline)
Eldepryl; Emsam (Selegiline)
Wellbutrin SR (Bupropion)
AMITRIPTYLINE (ELAVIL; ENDEP) MEDICATION GUIDE
What is Amitriptyline Hydrochloride, generic Elavil and Endep?
Amitriptyline is in a class of drugs called tricyclic antidepressants. Elavil affects chemicals in the brain that may become unbalanced and cause depression.
This medicine is used to relieve symptoms of depression such as feelings of sadness, worthlessness, or guilt; loss of interest in daily activities; changes in appetite; tiredness; sleeping too much; insomnia; and thoughts of death or suicide. Endep is also sometimes used to treat certain types of pain.
Amitriptyline may also be used for purposes other than those listed in this medication guide.
Amitriptyline (Elavil) indications and usage
This medication is indicated for the relief of symptoms of depression and anxiety. Endogenous depression is more likely to be alleviated than are other depressive states. Amitriptyline may also be used to treat chronic pain, bulimia (an eating disorder), to prevent migraine headaches, and to treat a pathological weeping and laughing syndrome associated with multiple sclerosis.
Side effects of amitriptyline
The common side effects reported with elavil generic are dry mouth, bad taste, epigastric distress, constipation, blurred vision, palpitation, increased apetite and weight gain, sedation, sweating, fine tremors, breast enlargement (in males and females), bone marrow depression, hair loss, heart attack, problems in urinating, rash, stroke, high body temperature, seizure, swelling of testicles and water retention.
Guidelines before using Amitriptyline HCl (Elavil; Endep) generic
Do not take this medication if you have taken a monoamine oxidase inhibitor such as isocarboxazid (Marplan), tranylcypromine (Parnate) or phenelzine (Nardil) within the last 14 days.
Before taking this drug, tell your health care provider if you have
- liver disease;
- kidney disease;
- thyroid disease;
- stomach or intestinal problems;
- high blood pressure or heart disease;
- an enlarged prostate or difficulty urinating;
- had a heart attack in the last 6 weeks;
You may not be able to take amitriptyline, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.
While you are taking Endep you may need to be monitored for worsening symptoms of depression and / or suicidal thoughts at the start of therapy or when doses are changed.
Elavil passes into breast milk and may affect a nursing baby. Do not take this drug without first talking to your doctor if you are breast-feeding a baby.
This medicine may be harmful to an unborn baby. Do not take amitriptyline hydrochloride without first talking to your doctor if you are pregnant or could become pregnant during treatment.
If you are over 60 years of age, you may be more likely to experience side effects such as dizziness, unsteadiness, drowsiness, feeling uncoordinated, and low blood pressure. Your doctor may prescribe a lower dose of this medication.
How should I take amitriptyline?
Take this medication exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.
Take each dose with a full glass (8 oz) of water.
This medicine may be taken several times a day or in one daily dose (usually at bedtime). Follow your physician's instructions.
Do not stop taking amitriptyline suddenly. This could cause symptoms such as nausea, headache, and malaise.
It may be 4 weeks or more before you start to feel better, but do not stop taking amitriptyline without first talking to your doctor.
What are the common dosages of Elavil and Endep generic?
The recommended starting dosage of amitriptyline hydrochloride is 75 mg / day in divided doses. In severely depressed patients a maximum of 150 mg / day can be given in divided doses. The increase in doses are preferably made in late afternoon or bed time doses as it cause a sedative effect before anti depressant action. 10 mg, 3 times a day, and 20mg at bed time is satisfactory in adolescent and elderly patients as they cannot tolerate higher doses. This medication is not recommended for children under 12 years of age.
What if I miss a dose?
Take the missed dose as soon as you remember. If it is almost time for the next regularly scheduled dose, skip the missed dose and take the next one as directed. Do not take a double dose of Elavil unless otherwise directed by your doctor.
What happens if I overdose?
Seek emergency medical attention.
Symptoms of amitriptyline hcl overdose include confusion, seizures, drowsiness, hallucinations, agitation and low blood pressure (dizziness, fatigue, fainting).
What may interact with this medicine?
certain medicines used to regulate abnormal heartbeat or to treat other heart conditions
other medicines for mental depression
MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate
phenothiazines like perphenazine, thioridazine and chlorpromazine
St. John's Wort
Amitriptyline may also interact with the following substances:
atropine, hyoscyamine, scopolamine, tolterodine and other related drugs
barbiturate medicines for inducing sleep or treating seizures, like phenobarbital
thyroid hormones such as levothyroxine
This list may not describe all possible interactions. Give your doctor or pharmacist a list of all the medicines, non-prescription drugs, herbs and dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with amitriptyline.
Where should I keep amitriptyline tablets or capsules?
Keep out of the reach of children.
Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Throw away any unused medicine after the expiration date.
What is the difference between brand and generic Amitriptyline (Elavil; Endep)?
Brand and generic Elavil and Endep in oral capsules and tablets contains "amitriptyline hydrochloride" as the active pharmaceutical ingredient and hence the mechanism of action is the same. The difference between brand and generic forms are packaging, pricing and the brand name. Generic variants are priced cheaper because there are no brand names associated with it as well as no expenses towards research and development. You can buy cheap amitriptyline medicine when it is sold as a generic variant.
Where and how to buy Elavil or to buy Endep / generic amitriptyline hydrochloride online?
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Here is a list of some medications containing "Amitriptyline" as a main active pharmaceutical ingredient (API) of amitriptyline drugs, their trade names, available forms, doses and also pharmaceutical companies - manufacturers, distributors and suppliers, researchers and developers:
|Trade name of the drug
||Pharmaceutical forms and doses
||Tablets, Film-Coated; Oral; Amitriptyline Hydrochloride 10 mgTablets, Film-Coated; Oral; Amitriptyline Hydrochloride 25 mg
||Tablets; Oral; Amitriptyline Hydrochloride 10 mgTablets; Oral; Amitriptyline Hydrochloride 100 mgTablets; Oral; Amitriptyline Hydrochloride 150 mgTablets; Oral; Amitriptyline Hydrochloride 25 mgTablets; Oral; Amitriptyline Hydrochloride 50 mgTablets; Oral; Amitriptyline Hydrochloride 75 mg
||Tablets, Film-Coated; Oral; Amitriptyline Hydrochloride 25 mgTablets, Film-Coated; Oral; Amitriptyline Hydrochloride 50 mgTablets, Film-Coated; Oral; Amitriptyline Hydrochloride 75 mgTablets; Oral; Amitriptyline Hydrochloride 10 mgTablets; Oral; Amitriptyline Hydrochloride 25 mgTablets; Oral; Amitriptyline Hydrochloride 50 mgTablets; Oral; Amitriptyline Hydrochloride 75 mg
||ApotexHind WingNhan TamPharmaforte
||Tablets; Oral; Amitriptyline Hydrochloride 10 mg
||Injectable; Injection; Amitriptyline Hydrochloride 10 mg / mlTablets, Film-Coated; Oral; Amitriptyline Hydrochloride 25 mgTablets; Oral; Amitriptyline Hydrochloride 10 mgTablets; Oral; Amitriptyline Hydrochloride 100 mgTablets; Oral; Amitriptyline Hydrochloride 150 mgTablets; Oral; Amitriptyline Hydrochloride 25 mgTablets; Oral; Amitriptyline Hydrochloride 50 mgTablets; Oral; Amitriptyline Hydrochloride 75 mg
||MerckAA PharmaAstraZenecaCyril PharmaceuticalsDDSA PharmaceuticalsGerda LaboratoiresOntarioSubstipharm Laboratoire
||Concentrate; Oral; Amitriptyline Hydrochloride 40 mg / mlTablets; Oral; Amitriptyline Hydrochloride 10 mgTablets; Oral; Amitriptyline Hydrochloride 100 mgTablets; Oral; Amitriptyline Hydrochloride 150 mgTablets; Oral; Amitriptyline Hydrochloride 25 mgTablets; Oral; Amitriptyline Hydrochloride 50 mgTablets; Oral; Amitriptyline Hydrochloride 75 mg
||Injectable; Injection; Amitriptyline HydrochlorideTablets, Film-Coated; Oral; Amitriptyline Hydrochloride 50 mg
||Bayer Schering PharmaGerolymatosLundbeckRoche
||Injectable; Injection; Amitriptyline HydrochlorideTablets, Film-Coated; Oral; Amitriptyline Hydrochloride 10 mgTablets, Film-Coated; Oral; Amitriptyline Hydrochloride 25 mgTablets, Film-Coated; Oral; Amitriptyline Hydrochloride 50 mg
||Tablets; Oral; Amitriptyline Hydrochloride 10 mgTablets; Oral; Amitriptyline Hydrochloride 25 mgTablets; Oral; Amitriptyline Hydrochloride 75 mg
||MerckFulcrum Medical Marketing
||Tablets; Oral; Amitriptyline Oxide 30 mgTablets; Oral; Amitriptyline Oxide 60 mgTablets; Oral; Amitriptyline Oxide 90 mgTablets; Oral; Amitriptyline Oxide 120 mg
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